GABA and L-Theanine: Your Dynamic Duo for Creating Calm, Relaxation and Glowing Skin

Gaba and L-Theanine are amino acids that are a perfect pairing for managing stress. A dynamic duo! They help in so many ways, from combating stress and anxiety to improving academic and athletic performance and more. When taken together Gaba and L-Theanine have everything you could want in a supplement. Let’s take a look at some of GABA and L-Theanine’s benefits and how you may put them to work for you to feel relaxed, refreshed and rejuvenated!


GABA is a naturally occuring amino acid in the brain and serves as a significant chemical messenger (neurotransmitter) in our central nervous system. Studies have shown that deficiencies in neurotransmitters like GABA may cause emotional issues including anxiety and depression.

So what does GABA do? GABA blocks nerve impulses, slowing down their activity and preventing them from over-firing. This proves to be very beneficial because it acts as a vital calming agent for the body, helping to squash stress and anxiety. Supplementation with GABA may be of benefit in helping to cope with stressful scenarios, whether induced by the chronic daily grind or an acute or extremely stressful scenario.


L-Theanine is an amino acid found primarily in tea (especially green tea). It’s ability to cross the blood brain barrier enables it to have an impact on the brain’s activity and have anti-stress effects. It is known that L-theanine has positive effects on mood, cognitive performance, cancer, cardiovascular disease, obesity and the common cold. What’s more is studies suggest that L-theanine increases our feel good neurotransmitters including serotonin, dopamine and GABA furthering the body’s ability to reduce anxiety so that you experience calm and relaxation.

GABA and L-Theanine help relax the mind, calm the gut and boost performance

To understand how our brains react to real life situations, our brain waves can be analyzed by using a test called an electroencelphalogram or EEG. Alpha waves are produced anytime the body is relaxed but alert, like during meditation. In contrast, Beta waves are observed during high stress situations and when there’s challenges concentrating and focusing. Studies have shown that supplementation with GABA and L-theanine:

  • Help induce relaxation and reduce anxiety by increasing the production of alpha waves while decreasing beta waves

  • Support mental calm and allow for clear thinking, better focus and concentration boosting academic and athletic performance

  • Help improve sleep quality by promoting faster onset and longer duration of sleep

  • Activate the parasympathetic nervous system responsible for the “rest and digest” response contributing to positive effects on stress related gastrointestinal problems including irritable bowel syndrome.

Keep these amino acids handy if you’re struggling with stress or concentration. Although they can help relieve sleepless nights, they don’t cause daytime drowsiness which is win-win! They can help you stay on track by dialing in your focus and reducing anxiety in a few short minutes. Designs for Health made Liposomal Neurocalm and Neurocalm capsules for just these reasons. These supplements are fast acting, and the capsules have a few extras that I’ve found to be what I need to help me get the rest I need.

GABA and L-Theanine help rejuvenate your skin and reduce inflammation

Stress, both acute and chronic can wreck havoc on your skin. Recent research has highlighted skin both as an immediate stress perceiver as well as a target of stress responses. The skin’s stress response may manifest as exacerbation of conditions like eczema, psoriasis, acne, impaired wound healing and accelerated breakdown of the skin’s supportive tissues collagen and elastin leading to increased fine lines and wrinkles. Recent research has shown that supplementation with GABA and L-Theanine:

  • Upregulated expression of collagen and significantly increased skin elasticity

  • Help reduce itch from both local skin disorders and chronic systemic conditions contributing to itch like kidney and liver disease

  • Decrease skin inflammation and irritation by downregulating the body’s main inflammatory chemicals Interleukin-1 beta, interferon-alpha and cyclo-oxygenase 2

Even if you have your healthy diet dialed in, both acute and long-term relentless stress can be obstacles to you feeling, looking and performing your best. Supporting your body’s response to stress and boosting calm and relaxation are key to help address this aspect of your health so that your skin glows and you feel your mood and mind are in the flow. Designs for Health Liposomal Neurocalm has superior absorption and intracellular delivery of nutrients making it fast acting and effective, and Neurocalm capsules have a bunch of extras to make it even better.

If you want the amazing benefits of gaba and L-theanine together, try a bottle of Liposomal Neurocalm* or Neurocalm* capsules today.

Use the code FIRST15TODAY to receive 15% off your first order!

You can also find GABA and L-Theanine separately in most health and wellness markets. Either way, make sure that before you start any new supplement you check in with your healthcare provider to make sure it is an appropriate choice and doesn’t interfere with your current medications or supplement regimen.



  1. Türközü D, Şanlier N. L-theanine, unique amino acid of tea, and its metabolism, health effects, and safety.Crit Rev Food Sci Nutr. 2017 May 24;57(8):1681-1687

  2. Uehara E, Hokazono H, Hida M, Sasaki T, Yoshioka H, Matsuo N.GABA promotes elastin synthesis and elastin fiber formation in normal human dermal fibroblasts (HDFs) Biosci Biotechnol Biochem. 2017 Jun;81(6):1198-1205.

  3. McMenamin CA, Travagli RA, Browning KN. Inhibitory neurotransmission regulates vagal efferent activity and gastric motility.Exp Biol Med (Maywood). 2016 Jun;241(12):1343-50

  4. Zeng WJ, Tan Z, Lai XF, Xu YN, Mai CL, Zhang J, Lin ZJ, Liu XG, Sun SL, Zhou LJ.Topical delivery of l-theanine ameliorates TPA-induced acute skin inflammation via downregulating endothelial PECAM-1 and neutrophil infiltration and activation.Chem Biol Interact. 2018 Mar 25;284:69-79.

  5. Hasler G, van der Veen JW, Grillon C, Drevets WC, Shen J. Effect of Acute Psychological Stress on Prefrontal GABA Concentration Determined by Proton Magnetic Resonance Spectroscopy. The American journal of psychiatry. 2010;167(10):1226-1231.

  6. Song X, Wang H, Zheng L, Chen D, Wang Z. The relationship between problem behavior and neurotransmitter deficiency in adolescents. J Huazhong Univ Sci Technolog Med Sci. 2010 Dec;30(6):714-9. doi: 10.1007/s11596-010-0646-7.

  7. Abdou AM, Higashiguchi S, Horie K, Kim M, Hatta H, Yokogoshi H. Relaxation and immunity enhancement effects of gamma-aminobutyric acid (GABA) administration in humans. Biofactors. 2006;26(3):201-8.

  8. Yoto A, Motoki M, Murao S, Yokogoshi H. Effects of L-theanine or caffeine intake on changes in blood pressure under physical and psychological stresses. Journal of Physiological Anthropology. 2012;31(1):28.

  9. Kimura K, Ozeki M, Juneja LR, Ohira H. L-Theanine reduces psychological and physiological stress responses. Biol Psychol. 2007 Jan;74(1):39-45.

  10. Nathan PJ, Lu K, Gray M, Oliver C. The neuropharmacology of L-theanine(N-ethyl-L-glutamine): a possible neuroprotective and cognitive enhancing agent. J Herb Pharmacother. 2006;6(2):21-30.

  11. Nobre AC, Rao A, Owen GN. L-theanine, a natural constituent in tea, and its effect on mental state. Asia Pac J Clin Nutr. 2008;17 Suppl 1:167-8.

  12. Taylor CP, Gee NS, Su TZ et al. A summary of mechanistic hypotheses of gabapentin pharmacology. Epilepsy Res. 1998 Feb;29(3):233-49.

  13. Taylor CP. Mechanisms of action of gabapentin. Rev Neurol (Paris). 1997;153 Suppl 1:S39-45.

  14. Jembrek MJ, Auteri M, Serio R, Vlainic J. GABAergic System in Action: Connection to Gastrointestinal Stress-related Disorders. Curr Pharm Des. 2017;23(27):4003-4011.

  15. Aggarwal S, Ahuja V, Paul J. Dysregulation of GABAergic Signalling Contributes in the Pathogenesis of Diarrhea-predominant Irritable Bowel Syndrome. Journal of Neurogastroenterology and Motility. 2018;24(3):422-430.

  16. Bhat R, Axtell R, Mitra A, et al. Inhibitory role for GABA in autoimmune inflammation. Proceedings of the National Academy of Sciences of the United States of America.2010;107(6):2580-2585.

  17. Crowley T, Cryan JF, Downer EJ, O'Leary OF. Inhibiting neuroinflammation: The role and therapeutic potential of GABA in neuro-immune interactions. Brain Behav Immun. 2016 May;54:260-277. doi: 10.1016/j.bbi.2016.02.001.

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Resilient Health Institute

Gig Harbor, WA, USA

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